Hyalruonic Acid (HA)
Hyaluronic Acid is a naturally occurring molecular compound found in the skin. It's responsible for maintaining hydration in the skin and retaining moisture. HA fillers use the same water-retaining function and are typically soft and gel-like. These types of dermal filers are temporary and last anywhere from 6 to 12 months before they are gradually broken down dissipated by the body. The most common HA fillers that are FDA approved for use are:
- Juvederm: Juvederm XC, Voluma, Volbella, Vollure
- Restylane: Restylane, Restylane Silk, Restylynae Lyft, Restylane Refyne, and Restylane Defyne
- Belotero Balance
Calcium Hydroxyapatite (CaHA)
Calcium Hydroxyapatite is also a naturally occurring molecule found mostly in our bones. When this molecule is used as an injectable filler, the calcium particles are held in suspension by a smooth gel. This filler is typically thicker than a hyaluronic acid filler and therefore is injected to maintain more structure and will typically last anywhere from 12 to 18 months for most patients. Calcium hydroxyapatite is also reported to stimulate natural collagen production by the body, thus allowing for more longer term rejuvenation. This product is usually used to soften deeper lines and wrinkles. An FDA-approved CaHA filler includes Radiesse.
Poly-L-lactic Acid
The Poly-L-lactic Acid is a biocompatible molecule that has been used for many years in medical applications such as dissolvable stitches. This product is known as a collagen modulator. Their main purpose is to soften fine lines and allowing your skin to naturally build it's own collagen to restore volume loss. The difference with this injectable is that the initial product will appear more volumizing for the initial days after injection, and will subside. Consequently, the body will be stimulates to produce natural collagen in the areas injected allowing for a deeper facial volume loss restoration with effects that can last more than 24 months. FDA approved Poly-L-lactic acid fillers include Sculptra Aesthetic.
Polymethymethacrylate (PMMA)
Polymethylmethacrylate (PMMA) is a synthetic, but biocompatible substance that has been used in the medical field for the last 100 years. With regards to the use of this substance in dermal fillers, PMMA takes the form of microsphere, or tiny ball, that remains benath the skin permanently to provide continued tissue support. PMMA fillers also contain naturally occurring collagen which not only provides structure, but also firmness where injected. This is a popular dermal filler used for acne scars that provides volume restoration under deeper scars. FDA approved PMMA fillers include Bellafill.